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[(Medical)-302.8(cannabis)-301.2(use)-303.7(was)-296.4(rst)-301.4(legalized)-301.7(in)-306.1(the)-297.8(state)-305.2(of)]TJ
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22.9068 57.9085 TD
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T*
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1.0036 -1.1795 TD
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[(with)-366.5(additional)-365.1(questions)-366.8(about)-363.8(cannabis.)-367.7(It)-363.4(included)]TJ
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[(demographic)-285.8(information,)-281.7(employment)-280.8(history,)-282.8(insur-)]TJ
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T*
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11.0965 0 TD
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[(ion)-332.9(a)-2.3(sked,)-340.3()47.7()-4.1(D)0(oes)-334(t)-2.8(he)-333.7(use)-338.9(o)-1.4(f)]TJ
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1.0036 -1.1795 TD
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[(necessary.)-217(Reasons)-219.7(for)-215.9(wanting)-213.9(to)-211.9(use)-215.8(medical)-215.4(cannabis)]TJ
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[(were)-237.7(discussed.)-238.7(The)-234.1(history)-231.8(was)-239.5(followed)-232.8(by)-231.8(a)-235.5(standard)]TJ
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[(physical)-333.5(examination.)-327.8(Once)-334.9(the)-328.8(intake)-333(evaluation)-328(was)]TJ
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[(recommendation)-203.8(if)-204.3(the)-199.5(physician)-201.6(thought)-203.1(it)-198.5(would)-202.4(ben-)]TJ
T*
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0 -1.1795 TD
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T*
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[(oids)-285.6(taken)-287.8(for)-283.2(at)-285.3(least)-284.8(6)-286.6(months)-281.6(with)-283.8(an)-284.3(opioid)-285.3(dosing)]TJ
T*
[(frequency)-304.9(of)-295.4(three)-298.9(or)-300(more)-303.2(doses)-298.5(per)-298.5(day.)]TJ
1.0036 -1.1847 TD
[(All)-214.9(prescription)-216.9(opioid)-212.8(use)-215.8(was)-218.8(converted)-215.9(into)-212.8()42.1(mor-)]TJ
-1.0036 -1.1795 TD
[(phine)-484.2(equivalents)46.4()-485.6(\(MEs\))-482.8(using)-485(standardized)-484.9(guide-)]TJ
0 -1.1847 TD
(lines.)Tj
8.2191 0 0 7.3052 82.2614 573.2219 Tm
(29)Tj
10.959 0 0 10.959 95.4141 568.3463 Tm
[(The)-482.4(amount)-483.4(of)-481.6(time)-481(it)-483(took)-480(for)-484.9(patients)-484.4(to)]TJ
-3.2539 -1.1795 TD
[(stop)-331.6(opioids)-324.8(\(or)-329.4(who)-330.2(continued)-324.3(usage\))-333.1(was)-327.5(calculated)]TJ
0 -1.1847 TD
[(as)-337.1(the)-339.2(difference)-336.9(between)-337.7(when)-333.7(a)-339(patient)-336.3(was)-337.8(initially)]TJ
0 -1.1795 TD
[(seen)-451.3(and)-447.1(treated)-450.4(by)-449.1(the)-447.8(cannabis)-446(physician)-449.9(and)-447.1(the)]TJ
0 -1.1847 TD
[(date)-239.1(of)-233.3(visit)-233.9(when)-235.4(the)-235.7(patient)-232.8(was)-234.3(no)-236.8(longer)-233.5(taking)-234.1(opi-)]TJ
0 -1.1795 TD
[(oids)-301.1(\(or)-298.4(their)-299.8(last)-302.4(visit)-296(if)-302.6(they)-300.2(were)-299.8(still)-296.7(on)-298.9(opioids\).)]TJ
1.0036 -1.1795 TD
[(Because)-267.5(cannabis)-264.9(usage)-267.5(between)-265.3(patients)-267.2(was)-265.4(highly)]TJ
-1.0036 -1.1847 TD
[(variable)-225.1(in)-228.5(the)-225.4(methods)-228(of)-222.9(consumption,)-227.6(types)-226.6(of)-228.1(prod-)]TJ
0 -1.1795 TD
[(ucts)-208.6(used,)-207.2(frequency)-206.6(of)-202.3(usage)-205.4(and)-204(percentages)-207.7(of)-207.4(c)12.5(a)0(n)21(n)0(a)15.8(-)]TJ
0 -1.1847 TD
[(bi)20.2(no)16.7(i)11.7(d)-281.8(co)21(nc)20.6(en)15.5(t)12.3(r)12.2(at)19.9(io)20.2(ns)20.4(,)-283.8(w)0(e)-272.7(r)0(e)19.5(p)0(o)16.4(r)12.2(t)-282.6(t)0(h)20.8(e)-282.4(gr)20.2(am)17.8(s)-282.6(o)0(f)-274.7(c)12.5(an)21(na)15.8(b)13.7(i)0(s)]TJ
0 -1.1795 TD
[(used)-207.9(per)-205.4(day,)-208.7(recognizing)-201.8(that)-207.6(the)-204.7(bioavailability)-204.3(of)-202.3(var-)]TJ
0 -1.1847 TD
[(ious)-301.1(methods)-300.4(of)-300.5(consumption)-300.7(such)-300.4(as)-295.7(inhalation)-302(\(e.g.,)]TJ
0 -1.1795 TD
[(smoking)-362.8(and)-359.2(vaporization\))-357.7(are)-366(highly)-357.3(variable)-359.6(within)]TJ
0 -1.1847 TD
[(and)-354(between)-353.3(groups)-357.2(such)-352.1(as)-352.6(ingestion)-351.7(\(e.g.,)-358.7(tinctures,)]TJ
0 -1.1795 TD
[(pills,)-326.3(and)-323(edibles\).)-323.9(For)-323.2(smoking,)-325.9(we)-324.5(assumed)-322.8(that)-321.4(one)]TJ
0 -1.1847 TD
[(joint)-356(was)-353.3(0.32)-166(g)-349(o)0(f)-357.4(cannabis.)]TJ
8.2191 0 0 7.3052 186.1228 378.9353 Tm
(30)Tj
10.959 0 0 10.959 197.8582 374.0597 Tm
[(For)-354.2(ingestion,)-351(we)-355.5(used)]TJ
-12.6018 -1.1795 TD
[(the)-323.7(reported)-322.7(amount)-323(of)-321.2(cannabis)-321.8(per)-324.4(patient-reported)]TJ
T*
(product.)Tj
1.0036 -1.1847 TD
[(To)-200(determine)-200.2(differences)-200.5(between)-203.2(patients)-199.9(who)-200.9(stop-)]TJ
-1.0036 -1.1795 TD
[(ped)-204.6(using)-205.6(opioids)-205.8(and)-204(those)-204.6(who)-200.9(continued)-205.4(with)-201(regard)]TJ
0 -1.1847 TD
[(to)-537.9(various)-537.2(demographics,)-536.7(cannabis)-539.1(use,)-540.9(and)-535.1(opioid)]TJ
0 -1.1795 TD
[(us)20.1(e,)-224.8(Fi)19.5(s)12.2(h)0(e)15.8(r)12.2()11.1(s)-236.1(e)12.5(x)0(a)20.4(c)0(t)-223.5(t)12.3(es)19.5(t)-230.8(w)0(a)17.3(s)-230.9(us)20.1(ed)-222.8(f)11.7(o)0(r)-222.4(c)0(a)20.1(t)0(e)19.6(g)0(o)21.6(r)0(i)18.7(c)0(a)20.1(l)-231.1(va)20.7(ri)18.7(ab)21.3(le)19.4(s,)]TJ
/F8 1 Tf
0 -1.1847 TD
(t)Tj
/F6 1 Tf
.3052 0 TD
[(-test)-502(for)-505.6(normally)-500.7(distributed)-503.8(continuous)-502.3(variables,)]TJ
-.3052 -1.1795 TD
[(and)-271.2(Wilcoxon)-271.8(rank)-269.3(sum)-269.8(for)-272.8(non-normal)-266(distributions.)]TJ
0 -1.1847 TD
[(To)-303.5(ascertain)-296.4(whether)-301.5(patients)-298.2(reduced)-299.2(their)-299.8(morphine)]TJ
0 -1.1795 TD
[(eq)20.7(ui)19.5(va)15.6(l)12(e)12.5(nt)20.5(s)-215.4(a)12.8(f)11.7(t)0(e)19.6(r)-210.2(st)19.3(ar)19.8(ti)18.8(ng)-201.2(c)12.5(a)0(n)21(n)0(a)15.8(b)13.7(is)18.7(,)-211.4(r)12.2(eg)20.4(ar)19.8(dl)19.9(es)19.5(s)-210.2(o)0(f)-202.3(w)0(h)23.3(e)0(t)19.6(h)0(e)15.8(r)]TJ
T*
[(patients)-406.8(stopped)-406.8(using)-407.4(opioids,)-406.8(the)-401.3(sign)-410.1(test)-400.8(and)-410.9(the)]TJ
0 -1.1847 TD
.0197 Tc
[(Wil)-4.5(c)1.2(oxon)-520.5(sign)-520.5(rank)-520.8(tes)-4.3(t)-516.4(was)-521.6(u)1.7(s)-4.3(e)1.2(d.)-522.8(To)-520.1(det)-4.2(e)1.2(rmine)]TJ
0 -1.1795 TD
0 Tc
[(which)-419.9(patient)-419.1(factors)-419.6(might)-420.2(predict)-419.7(who)-413(would)-419.7(stop)]TJ
0 -1.1847 TD
[(opioids,)-572.4(logistic)-568.1(regression)-572.7(models)-567.8(were)-568.8(developed.)]TJ
0 -1.1795 TD
[(All)-287.4(analyses)-292.2(were)-284.2(performed)-292.5(using)-288.4(SAS)-285.9(statistical)-289.4(soft-)]TJ
0 -1.1847 TD
[(ware)-258.1(\(version)-256.3(9.4;)-256.3(SAS)-254.9(Institute,)-259.8(Cary,)-251.9(NC\).)-258.1(The)-254.8(West-)]TJ
0 -1.1795 TD
[(ern)-313.7(Institutional)-313(Review)-309.5(Board)-311.9(approved)-310.5(this)-312.2(study)-314(as)]TJ
0 -1.1847 TD
(exempt.)Tj
/F3 1 Tf
10.4607 0 0 10.4607 59.7543 115.0299 Tm
(Results)Tj
/F6 1 Tf
10.959 0 0 10.959 59.7543 102.1039 Tm
[(The)-254.8(active)-256.2(database)-249.6(of)-254(patient)-253.5(records)-253.1(showed)-256.3(that)-249(180)]TJ
0 -1.1795 TD
[(patients)-303.4(had)-301.9(a)-297.6(chief)-300.1(complaint)-302.3(of)-300.5(lower)-296.8(back)-299.7(pain)-300.9(and)]TJ
0 -1.1847 TD
[(carried)-435.6(the)-432.3(corresponding)-428.4(ICD-10)-430.9(code)-429.4(\()-86.4(M54.5\).)-432.3(Of)]TJ
0 -1.1795 TD
[(180)-327.1(patients,)-323.3(113)-321.9(patients)-324.1(were)-325.6(excluded)-322.9(because)-324.6(they)]TJ
22.912 57.9085 TD
[(were)-522.2(not)-524.5(taking)-529(any)-524.6(prescribed)-526.3(opioid)-523.2(medications)]TJ
0 -1.1847 TD
[(when)-204.3(they)-201.9(were)-201.5(initially)-204.9(evaluated.)-206(Six)-205.9(patients)-199.9(were)-206.6(ex-)]TJ
0 -1.1795 TD
[(cluded)-327.4(because)-324.6(they)-326.1(did)-329.6(not)-322.8(have)-325.6(any)-328.1(follow-up)-323.1(visits)]TJ
0 -1.1847 TD
[(after)-367.9(their)-367(initial)-364.6(evaluation)-369.4(for)-365.9(a)-370(nal)-367.2(sample)-367(size)-365(of)]TJ
0 -1.1795 TD
[(61)-299.1(patients)-298.2(\(Fig.)-301.3(1\).)]TJ
.9984 -1.1847 TD
[(Patients)-421.7(were)-418.7(50.1)]TJ
/F5 1 Tf
7.7184 0 TD
()Tj
/F6 1 Tf
.7139 0 TD
[(11.4)-419.5(years)-423.5(of)-414.4(age)-422(\(range)]TJ
/F5 1 Tf
10.2015 0 TD
(=)Tj
/F6 1 Tf
.7191 0 TD
(49)Tj
-20.3513 -1.1795 TD
[(86\),)-431.3(62%)-428.5(men)-434.8(with)-428.6(the)-432.3(majority)-429.7(\(85%\))-430.6(being)-432.3(white.)]TJ
T*
[(The)-332.4(mean)-339.2(level)-331(of)-336.8(education)-335.2(was)-337.8(13.7)]TJ
/F5 1 Tf
15.5712 0 TD
()Tj
/F6 1 Tf
.7139 0 TD
[(2.5)-334.6(years.)-340(Fif-)]TJ
-16.2851 -1.1847 TD
[(teen)-373.6(percent)-377.3(had)-374.4(military)-374.8(service.)-373(For)-374.9(religious)-379.3(a)-18.2(f)-19.4()-22.5(l)-19(i)-19.4(-)]TJ
0 -1.1795 TD
.0195 Tc
[(ation,)-367.8(52.3%)-363.4(wer)-4.5(e)-361.2(Chri)-5(stian,)-362.6(31.8%)-363.4(w)-1.9(ere)-366.3(n)1.8(one,)-367.8(and)]TJ
0 -1.1847 TD
0 Tc
[(1)13.4(5)0(.)19.3(9)0(%)-328.1(w)0(e)17(r)12.2(e)-339.3(o)0(t)20.8(h)0(e)21(r)0(.)-333.7(F)13(or)-331(e)12.5(m)10.2(pl)19.9(oy)16.5(m)15.3(e)0(n)15.5(t)-339.5(s)12.2(t)12.3(at)19.9(us)20.1(,)-340.7(7)0(7)21.7(.)0(8)19.3(%)-341.5(we)22.1(re)]TJ
0 -1.1795 TD
.0091 Tc
[(empl)-4.7(oye)-4.3(d)-474.5(and)-479.7(2)1.8(2.2%)-477.3(were)-480.2(unemployed,)-481.6(r).6(et)-4.5(ire)-4.3(d)1.4(,)-476.5(o)-3(r)]TJ
0 -1.1847 TD
0 Tc
[(had)-301.9(unknown)-303.7(employment)-306.6(status.)-302.1(For)-307.6(insurance)-305.5(type,)]TJ
0 -1.1795 TD
[(75.4%)-336.8(had)-343.3(private,)-346.2(21.1%)-336.8(public,)-342.3(and)-343.7(3.5%)-339.9(had)-343.3(none.)]TJ
0 -1.1847 TD
[(Forty-ve)-385.6(percent)-387.6(smoked,)-390.2(34.4%)-388.5(drank)-385.6(any)-390.1(alcohol,)]TJ
0 -1.1795 TD
[(and)-390.2(19.6%)-388.5(had)-389.9(ever)-389.4(used)-389(any)-390.1(illegal)-389.8(drugs)-391.7(excluding)]TJ
T*
(cannabis.)Tj
.9984 -1.1847 TD
-.0228 Tc
[(The)-212.1(p).6(atients)-207.2(r)-.2(eported)-206.4(m)-2.3(edian)-206(y).7(ears)-207.2(of)-207.7(chronic)-206.9(p).6(ain)-211.2(w)2.4(as)]TJ
-.9984 -1.1795 TD
.0131 Tc
[(11)-496(\(r)-5.7(an)-4.6(ge)]TJ
/F5 1 Tf
4.2989 0 TD
0 Tc
(=)Tj
/F6 1 Tf
.7346 0 TD
.5047 Tc
[(1)492.2()487(5)487.1(0)492.2(\))485.6(.)-1.5(T)492.7(h)487.3(em)489(e)486.2(d)491.9(i)485.3(a)491.6(nt)486(i)490.5(m)489(ep)486.7(a)486.5(t)491.1(i)490.5(e)486.2(n)487(t)491.1(sw)488.5(e)491.3(r)485.9(e)]TJ
-5.0335 -1.1847 TD
0 Tc
[(o)13.7(n)-431.6(op)21.6(i)11.7(o)0(i)20.2(d)0(s)-419.7(w)0(a)17.3(s)-427.5(3)-431.5(y)13.1(ea)20.1(rs)-420.5(\()11.9(r)0(a)19.8(n)0(g)16.1(e)]TJ
/F5 1 Tf
12.6381 0 TD
(=)Tj
/F6 1 Tf
.7087 0 TD
[(0.)19.3(1)13.4()0(2)16.4(0)13.4(\).)-421.9(Th)22.4(e)-432.4(m)10.2(e)12.5(d)0(i)19.5(a)0(n)]TJ
-13.3468 -1.1795 TD
[(m)10.2(o)13.7(rp)20.1(hi)20.2(ne)-238(eq)20.7(ui)19.5(va)20.7(le)19.3(nt)20.5(s)-246.4(u)0(s)20.1(e)0(d)-238.3(w)0(a)22.4(s)-251.6(2)13.4(1)-157.3(m)10.2(g)13.1(/d)19.5(ay)-237.9(\(r)19(an)21(ge)]TJ
/F5 1 Tf
19.4511 0 TD
(=)Tj
/F6 1 Tf
.7087 0 TD
[(1.)19.3(1)]TJ
-20.1598 -1.1847 TD
[(5)13.4(0)0(0)21.7(\))0(.)-282.2(T)0(h)17.2(e)-287.6(m)10.2(e)12.5(di)19.5(an)-284.3(a)12.8(m)10.2(ou)21.6(nt)-279.6(of)-279.9(ca)20.1(nn)21.5(ab)16.2(i)11.7(s)-287.8(us)20.1(ed)-284.9(w)14.8(a)0(s)-280.2(1)0(.)19.3(4)0(5)-143.9(g)0(/)]TJ
0 -1.1795 TD
[(d)13(a)0(y)-538(\()11.9(ra)19.8(ng)21.3(e)]TJ
/F5 1 Tf
4.6041 0 TD
(=)Tj
/F6 1 Tf
.7087 0 TD
[(0)13.4(.)0(0)19.3(1)0()21.6(1)0(8)16.5(.)11.1(7)-157.3(g)13.1(\))-546.8(w)0(i)21.3(t)12.3(h)-545(t)0(h)20.8(e)-546.2(m)10.2(a)12.8(jo)20.6(ri)18.7(t)12.3(y)-545.6(sm)17.2(o)13.7(k)0(i)19.6(n)0(g)]TJ
-5.3128 -1.1847 TD
-.0119 Tc
[(\(4)-11.9(4)9.7(/)-11.9(6)7.9(1)]TJ
/F5 1 Tf
2.6849 0 TD
0 Tc
(=)Tj
/F6 1 Tf
.7087 0 TD
[(7)13.4(2)0(%)18.5(\))11.9(.)-397.6(L)13.7(es)19.5(se)19.5(r)-396.5(u)0(s)20.1(e)0(d)-383.2(m)10.2(od)16.4(a)12.8(l)12(it)18.8(ie)19(s)-396.5(i)11.7(nc)20.7(l)12(u)0(d)15.7(e)12.5(d)-395.7(v)0(a)20.7(p)0(i)19.5(n)0(g)]TJ
-3.3936 -1.1795 TD
-.0119 Tc
[(\(1)-11.9(6)9.7(/)-11.9(6)7.9(1)]TJ
/F5 1 Tf
2.6849 0 TD
0 Tc
(=)Tj
/F6 1 Tf
.7087 0 TD
[(2)13.4(6)0(%)18.5(\))11.9(,)-418.3(t)12.3(i)11.7(n)0(c)15.5(t)12.3(ur)20.1(e)12.5(s)-417.1(\()11.9(1)0(1)16.5(/)11.6(61)]TJ
/F5 1 Tf
9.1462 0 TD
(=)Tj
/F6 1 Tf
.7087 0 TD
[(18)21.7(%\))17(,)-413.1(e)12.5(di)19.5(bl)20.6(es)-404.7(\(9)20.2(/6)19.8(1)]TJ
/F5 1 Tf
7.9408 0 TD
(=)Tj
/F6 1 Tf
-21.1893 -1.1847 TD
-.0235 Tc
[(15)-4.9(%\))-6.4(,)-302.1(a)-5.5(nd)-305.3(c)-5.8(a)-.4(p)-5.3(s)-.9(ul)-6.3(es)-306.1(\(2)-4.9(/61)]TJ
/F5 1 Tf
9.7876 0 TD
0 Tc
(=)Tj
/F6 1 Tf
.6984 0 TD
-.022 Tc
[(3%;)-305.8(t).6(ot)-4.5(als)-304.7(d)-3.8(o)-303.2(n)1.7(ot)-299.4(e)-4.3(q)1.7(u)-3.8(a)1.1(l)-304.8(1)1.8(0)-3.4(0)1.8(%)]TJ
-10.486 -1.1795 TD
0 Tc
[(because)-252.2(patients)-251.6(used)-254.5(multiple)-255.1(modalities)-250.4(of)-254(consump-)]TJ
T*
[(tion\).)-231.2(When)-234.1(asked)-236.5(if)-235.3(cannabis)-233.9(modied)-233(other)-230.5(drug)-238.3(use,)]TJ
0 -1.1847 TD
[(48%)-278.5(of)-285(those)-277(who)-283.7(answered)-279.4(the)-282.3(question)-280.7(felt)-282.6(it)-281.2(dimin-)]TJ
0 -1.1795 TD
[(ished)-459.4(their)-460.1(pain/opioid)-460.8(medications,)-463.5(28%)-459.6(felt)-458.5(like)-462.9(it)]TJ
0 -1.1847 TD
[(h)13.7(a)0(d)-294.9(n)13.3(o)-301.8(e)12.5(ff)18.1(ec)19.8(t)-298.1(o)0(n)-293.7(t)12.3(he)21(i)11.7(r)-303.3(pa)20.7(i)11.7(n)-302.2(m)10.2(e)12.5(di)19.5(ca)20.1(ti)18.8(on)21.9(s,)-292.3(an)21(d)-302.5(2)13.4(4%)-291.9(we)22.1(re)]TJ
0 -1.1795 TD
(unsure.)Tj
.9984 -1.1847 TD
[(Thirty)-207.6(patients)-210.3(\(49%\))-208.1(were)-211.8(classied)-208.1(as)-207.8(chronic)-210.4(users)]TJ
-.9984 -1.1795 TD
[(and)-328.1(31)-330.1(\(51%\))-332.3(were)-325.6(classied)-332.3(as)-331.9(intermittent)-329.4(users.)-330.3(Of)]TJ
0 -1.1847 TD
[(the)-303(intermittent)-298.3(users,)-309.6(20)-299.1(\(64.5%\))-302.6(were)-304.9(short-term)-300.3(in-)]TJ
0 -1.1795 TD
[(termittent)-276.8(users)-279.3(and)-281.6(11)-278.4(\(35.5%\))-276.8(were)-279.1(infrequent)-282.8(inter-)]TJ
T*
[(mittent)-298.3(users.)]TJ
.9984 -1.1847 TD
[(Of)-284(the)-282.3(61)-278.4(patients)-282.7(who)-278.5(were)-284.2(taking)-280.7(opioids)-283.4(on)-278.2(their)]TJ
-.9984 -1.1795 TD
[(initial)-411.1(visit,)-414.2(32)-407.7(\(52.5%\))-411.3(were)-413.6(able)-409.4(to)-413.7(completely)-409(stop)]TJ
0 -1.1847 TD
[(opioids.)-479.3(Of)-475.4(the)-478.9(32)-480.2(patients)-479.3(who)-475.1(stopped)-479.3(opioids,)-479.3(2)]TJ
0 -1.1795 TD
[(were)-284.2(able)-290.4(to)-284.4(stop)-290.2(by)-288.7(transitionin)5.7(g)-292.1(t)0(o)-284.4(the)-287.4(opioid)-290.4(partial)]TJ
0 -1.1847 TD
[(agonist)-412.7(suboxone)-417.5(in)-414.7(combination)-414.6(with)-413.1(cannabis)-415(use.)]TJ
0 -1.1795 TD
.01 Tc
[(We)-360.3(excluded)-365(these)-365.5(t)1.6(wo)-364.3(patients)-365.8(from)-362.7(the)-360.3(r)-3.6(emaining)]TJ
0 -1.1847 TD
0 Tc
[(analyses)-375(because)-371.2(suboxone)-376.1(is)-374.4(a)-375.2(partial)-373.6(opioid)-373.2(agonist)]TJ
0 -1.1795 TD
[(and)-395.4(we)-391.7(wanted)-397.2(to)-393(study)-396.7(the)-396.1(effect)-392.5(of)-398.8(cannabis)-394.3(alone)]TJ
0 -1.1847 TD
[(in)-445.7(reducing)-447(opioids.)-448.2(Of)-449.5(these)-443.8(30)-449.1(remaining)-447.9(patients)]TJ
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